Moreover, insulin resistance of the adipose tissue, associated with overweight/obesity, contributes to the flux of FFA from adipose tissue to the liver through unrestricted lipolysis ( de novo lipogenesis, i.e., hepatic FFA synthesis, seems to contribute to lipid deposition ( Figure 2 The gut-derived incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) are responsible for the so-called incretin effect (i.e., the potentiation of glucose-stimulated insulin secretion after meal ingestion) ( Glucagon is a key hormone in the regulation of overall energy homeostasis during the fasting state and other energy-demanding situations
Clinical and Translational Medicine, 14 (3), Article e1636
As with any treatment that influences your body's systems, there are potential risks, such as hormonal shifts or other side effects
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Ziegelmann MJ, Viers BR, Montgomery BD, Avant RA, Savage JB, Trost LW
111 The only acceptable alternative endpoint in drug development, histological evidence, consists of the resolution of steatohepatitis and no worsening of liver fibrosis, or improvement in liver fibrosis of at least one stage without worsening of steatohepatitis