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But several critical details remain unclear

Food and Drug Administration (FDA) in 2017 as a treatment for Type 2 diabetes, but it is also used on an off-label basis to help people lose weight

Collectively, you can see why these are attractive features when targeting glucagon in the corporation of the treatment of diabetes and obesity. Activation of the glucagon receptor with the triple-hormone receptor agonist retatrutide is being investigated in a large phase 3 program that includes 14 trials, among them TRANSCEND-T2D-1 and TRIUMPH-1, and more than 22,000 participants

doi: 10.3389/fendo.2022.1017468