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The decrease of mtDNA content at young age may be a cause of NIODM.

Free radical buildup in the body causes oxidative stress, responsible for various diseases and premature aging signs

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doi: 10.1111/tpj.12032

For example, genetic polymorphisms in GSTs, GCL, and selenoprotein genes were shown to influence mercury body burdens among heavy fish consumers (measured as erythrocyte total mercury levels), as well as urine and hair mercury levels among dental professionals

Plasma total F2-isoprostanes is the most reliable indicator of oxidative stress damage, which occurs as a result of lipid peroxidation