Brain function: Brain fog, memory problems, cognitive impairment, insomnia, headaches (especially migraine), behavioural changes, learning problems, nominal aphasia Mood: Mood swings, irritability, depression, anxiety, hallucinations, delusions, psychosis Sensory: Peripheral paraesthesia (pins and needles), numbness, neuropathic pains, poor balance, reduced vibration sense or proprioception (joint position sense), tinnitus, ataxia, taste impairment, sometimes myelopathy Constitutional: Fatigue, anaemia (either macrocytic, or normocytic when also iron deficient or associated with thalassaemia minor), other cytopenia, abdominal complaints, malabsorption, failure to thrive, weight loss, diarrhoea, hyperpigmentation, glossitis, (aphthous) stomatitis, infertility, urinary tract infections Motor: Muscle weakness, altered reflexes (increased in degeneration of the spinal cord, reduced when peripheral neuropathy dominates), spasticity, seizures, cardiomyopathy Autonomic: Urinary and/or faecal incontinence, postural hypotension or dizziness, erectile dysfunction Diagnosing B 12 deficiency can be challenging because no single specific measurement exists to reliably diagnose or refute the presence of B 12 deficiency 11 12 26 27 (box 2)

By replenishing glutathione through IV therapy, you provide your body with the support it needs to combat some of the most common contributors to headaches and migraine
For those of you who want to learn more about the health benefits of the products you purchase, our Taste the Colours nutritional information system gives you insights and additional product information at a glance
Free Radic Biol Med 33:311322 Buffinton GD, Doe WF (1995) Depleted mucosal antioxidant defences in inflammatory bowel disease
SARC006: Phase II trial of chemotherapy in sporadic and neurofibromatosis type 1 associated chemotherapy-naive malignant peripheral nerve sheath tumors
NAD+ Boosters (e.g., NMN or NR) : While not peptides, NAD+ precursors can be stacked with FOXO4-DRI to support mitochondrial function and cellular energy, complementing its senolytic action