The use of folic acid supplements in pregnancy has been related to a decreased risk of gestational hypertension and preeclampsia (Reference Liu, Liu and Wang92,Reference De Ocampo, Araneta and Macera102) , whereas a systematic review of case-control studies showed that women with preeclampsia had significantly lower serum vitamin B 12 concentrations than normotensive pregnant women (Reference Mardali, Fatahi and Alinaghizadeh103)
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6 Structure Tirzepatide is a synthetic linear peptide, serves as a distinctive agonist for GIP/GLP-1 receptors, fashioned from the native sequences of GIP, GLP-1, and semaglutide, with the incorporation of distinct residues [44]
It also influences insulin regulation, which is crucial for managing body weight and fat storage
In EAT the drug reduced FABP4 and perilipin 1 ( PLIN1 ), but not ADIPOQ expression and on SAT it reduced PPAR coactivator 1-alpha ( PGC1) expression
