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It enters circulation and activates the same gene expression cascades throughout the body affecting collagen synthesis in skin, wound healing in connective tissue, and potentially neuroprotection in the nervous system

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Neither peptide has been through human clinical trials as a therapeutic agent all the safety data is preclinical

When the integrity of the BBB is breached, infiltrating blood components and immune cells activate perivascular glia, igniting an inflammatory cascade that accelerates neuronal damage