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Future research that elucidates the physiological effects of GLP-1 on glycogen metabolism and energy expenditure in humans would explain currently underinvestigated mechanisms that are likely to contribute to the clinical effects of these medications

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Coskun et al., 'LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept', Cell Metab

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Symptoms like nausea, vomiting, and diarrhea occurred more frequently in people taking GLP-1 drugs, with some studies reporting rates up to 17 percent higher than placebo

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