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Consistent with the binding affinities acquired by SPR, GLP-1 LX exhibited the weakest binding and dissociated from the column first at pH 6.3, followed by GLP-1 WT at pH 6.7 and Tanzeum at pH 6.9 (Fig

Furthermore, GLP-1R can also become internalized in response to GLP-1 and its analogs, indicating a complex regulatory mechanism that affects gene expression and protein activity [32]