Bioresour Technol 100:350355
doi: 10.1038/sj.ki.5002567 38 KangDHKanellisJHugoCTruongLAndersonSKerjaschkiDet al
A recent study including spontaneously hypertensive rats and controls (WKY) reported that UA therapy (16 mg/kg) induced Kruppel-like factor 2 (KLF2) expression, lowered vascular endothelial growth factor (VEGF)-A levels, reduced BBB leakage, and improved endothelial cell barrier integrity [194, 196]
We expect this user-friendly application will add value to our dataset by allowing additional data mining
Consequently, the continuous excavation of genes upstream and downstream of glutamine metabolism, which can influence cancer cell invasion and metastasis-related genes, will be a promising means to contribute to the design of clinically specific relevant inhibitors
The combined model output was validated by replicating Figs 2 and 6 from the Reed et al