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As with other incretin-based therapies, the most commonly reported adverse effects of retatrutide in Phase 2 trials were gastrointestinal in nature (Jastreboff et al., NEJM , 2023)

Nevertheless, there is widespread agreement that until now no pharmacological options are available to tackle the entire spectrum of clinical manifestations observed in PCOS [21]

Advances in gerontology = Uspekhi gerontologii , 20 (1), 7485

While some of these studies showed that the addition of GLP-1 therapies to insulin led to improvements in HbA1c, total insulin dose, and weight, the benefits were relatively modest and accompanied by some side effects like hypoglycemia (low blood sugar)

doi:10.1080/19390211.2026.2616440 Salem A, Ammar A, Kerkeni M, et al

It is frequently utilized for research purposes by scientists and researchers