semaglutide discontinuation Weight maintenance after of GLP-1 therapies US, Japan Patients With Diabetes

Circ Res 100:174190

Heres the context: serious adverse events are rare and typically associated with pre-existing conditions

Data sources The input parameters for the benefit-harm balance modelling were the relative treatment effects of GLP-1 RAs as compared to placebo, the benefit and harm outcome incidences in untreated individuals, and preference weights (relative importance) of the outcomes.24, 25, 26, 27 A careful selection of valid and applicable evidence relevant to the given decision context is a key step in a benefit-harm analysis.28, 29, 30 The relative treatment effect and baseline risks were obtained from RCTs

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