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Symptoms include nausea or vomiting, sweating, stomach pains, especially in the right upper abdomen where the liver resides, fatigue, weakness, yellowing of the eyes or skin and confusion or drowsiness in severe cases, Dr

Subjects homozygous for this mutation ( MTHFR 677TT genotype) exhibit reduced MTHFR activity and increased risk for a wide variety of cancers (41-43), but the evidence of an association between this polymorphism and cancer is inconsistent, with some reports suggesting a reduction in colorectal cancer risk with the T allele (44)

[DOI] [PMC free article] [PubMed] [Google Scholar] 1234.Mariani SA, et al

Nucleic Acids Res 49:75547570 Perea-Resa C, Wattendorf L, Marzouk S, Blower MD (2021) Cohesin: behind dynamic genome topology and gene expression reprogramming

Pediatr Res 47:1723

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