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The PepT1 (SLC15A1) transporter a proton-coupled oligopeptide transporter normally expressed in the small intestine is dramatically upregulated in the colon during inflammatory bowel disease

doi: 10.1083/jcb.101.5.1799 25 DuchesneM.RichardL.JMV.MagyL

This could make the therapies less effective and cause patients to grow frustrated