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Younce C, Kolattukudy P

Furthermore, mice treated with SRT1720, a potent, selective synthetic activator of SIRT1, were resistant to diet-induced obesity due to enhanced oxidative metabolism in skeletal muscle, liver, and brown adipose tissue, indicating the positive metabolic consequences of specific SIRT1 activation (227)

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At the cellular level, AOD-9604 exerts its primary effects through a complex mechanism involving beta-3 adrenergic receptors located on the surface of adipocytes (fat cells)