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138 Cholic acid (CA), one of the primary BAs synthesized in the liver, induces autophagy through the upregulation of protein kinase B (Akt) phosphorylation and downregulation of mammalian target of rapamycin (mTOR) phosphorylation and CYP2E1, promoting HCC cell growth and metastasis

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This leads to muscle breakdown

Singh, S.K

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Crucially, the same analysis finds that better prevention and obesity management could prevent 150 million new chronic-disease cases, save 13.5 million lives, and avoid $7 trillion in costs over that window, with even modest behavior change worth ~$125 billion/year and optimistic scenarios ~$465 billion/year