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If nausea , diarrhea, or constipation worsen rather than improve over 4 to 6 weeks at a stable dose, suspect issues beyond normal adaptation, including dietary factors, concurrent illness, or medication interactions
J Appl Physiol (1985) 2001
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For a cosmetic goal, this is arguably the wrong exposure profile: you disperse the compound throughout the body to (hypothetically) reach a target organ, the skin, that a topical route reaches directly and locally
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