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Moreover, reductions of circulating CTX-I are more pronounced following oral glucose administration than intravenous glucose infusion, further indicating that gut derived hormones, rather than glucose levels per se , modulate bone turnover

This involves clinical checks, lab tests, and risk assessments

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Phentermine is a norepinephrine reuptake inhibitor, may also contribute to MASLD improvement through caloric reduction, though its use in children is more limited

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At the cellular level, E4 directly targets Mller cells to attenuate reactive gliosis, preserving the critical Bcl-2/Bax and Bcl-xL/Bax pro-survival ratios and consequently mitigating mitochondrial-mediated apoptosis via reduced caspase-3 activation [52]