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What this study adds GLP-1 receptor agonist use was not associated with an increased risk of suicidal ideation, self-harm, or suicide compared with use of dipeptidyl peptidase-4 inhibitors or sodium-glucose cotransporter-2 inhibitors GLP-1 receptor agonists do not seem to increase the risk of suicidality among patients with type 2 diabetes Ethics statements Ethical approval The study protocol was approved by the Research Data Governance of the Clinical Practice Research Datalink (protocol 24_003735) and by the Research Ethics Board of the Jewish General Hospital, Montreal, Canada
After six months of treatment, about 25% of participants without the variants met the recommended HbA1c target, compared with 11.5% of those with the p.S539W variant and 18.5% of those with the p.D563G variant
tirzepatide is under patent protection until at least 2036
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