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ADP/O: Ratio of ADP molecules phosphorylated to oxygen atoms reduced, reflecting phosphorylation efficiency

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Delayed intervention may miss the optimal window for controlling inflammatory peaks, and treatment strategies should be adjusted according to individual tolerance

Systemic corticosteroids (prednisone) may be used for more extensive disease, though they are not appropriate for maintenance due to significant adverse effects with prolonged use

doi: 10.1016/j.cca.2020.05.041 237 SallenaveJ.-M.GuillotL

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