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Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice

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Takeuchi and Akira, 2010)

We used a semiquantitative neuropathological scoring system, and the sum of the analyzed affected areas (04) (i) and karyopyknotic cells in the brain areas (04) (ii) made (i) + (ii) a combined score (08) as follows

This missing link about the roles of molecular oxidative damage caused by pro-oxidant chemicals, and the antioxidant mechanisms as mediators of the costs of immune activation induced by anti- and pro-inflammatory mechanisms is an important gap in current knowledge 21,22