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After subcutaneous injection, the plasma concentration of semaglutide gradually increased, reaching maximum concentrations in 312 h, and then decreased with an average t 1/2 of 7.228.99 h, with peak concentrations of 24,943.33 1087.19 and 27,636.5 2331.98 ng/mL, respectively

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Perimenopause is the transitional phase before menopause, marked by fluctuating hormones , particularly estrogen, which gradually declines but not in a totally straight line

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Patients with severe gastrointestinal disease, such as gastroparesis, should be monitored carefully as tirzepatide may exacerbate symptoms due to its effects on gastric emptying