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SIRT1 targets over 100 different proteins involved in metabolism, stress responses, and longevity pathways, including the tumor suppressor p53, the transcriptional coactivator PGC-1, and the DNA repair protein Ku70. Through deacetylation of PGC-1, SIRT1 promotes mitochondrial biogenesis and oxidative metabolism, while deacetylation of p53 reduces apoptotic responses to mild stress, promoting cellular survival and longevity

Here is what each dose looks like at 10mg/mL: The advantage here is clear for higher doses

Study 2: Ng 2000, original characterization Citation: Ng F.M., Sun J., Sharma L., et al

Add 20 l of Substrate working solution, and incubate the plate at 37C for 20-40 min

H., & Satylganova, A

Sports Med (2026)