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Because tryptophan is an important carbon source, its extracellular degradation/ consumption imposes a metabolic challenge to both immune and tumor cells from the TME

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Conversion of 4-hydroxyproline to oxalate begins with its oxidation to 1 -pyrroline-3-hydroxy-5-carboxylate by proline dehydrogenase 2 (encoded by the PRODH2 gene)

ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation

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