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In the regulation of innate immunity, the lack of the expression of NRF-2 entails a disturbance in the protective process of the host, as well as increased damage by hyperoxia, the increase of ROS, and inefficiency in the elimination and increase in the production of proinflammatory cytokines [28,29]

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Another study determined that 3000 mg NR supplementation per day in 20 PD patients without moderate or severe side effects for four weeks is well tolerated 313

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