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Inhibition of beta-TrcP-dependent ubiquitination of p53 by HIV-1 Vpu promotes p53-mediated apoptosis in human T cells

The transcriptional program induced by cystine deprivation is similar to that of leucine starvation 14 , suggesting that the transcriptional program is a common adaptation of amino acid starvation to activate amino acid metabolism and stress resistance

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Hsp90 binding enhances phosphorylation at Ser1177 by recruiting kinases such as Akt, which further boosts NO production (Fontana et al., 2002)

The dehydrogenation reaction catalyzed by glucose 6-phosphate dehydrogenase is the committed step in this pathway

Bull Exp Biol Med 2012;153:2558