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However, there are cases where medical therapy may be necessary, if the patient cannot tolerate surgery or localization of the abnormal gland is not possible

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Plasma membrane rupture in necrotic cells releases DAMPs, including HMGB1, ATP, and mtDNA, which activate microglia and astrocytes via pattern recognition receptors (e.g., TLR4, purinergic 2X7 receptor (P2X7R)) [184]