Early GLP-1 RAs (exenatide) [archived link] and exenatide ER [archived link]) were designed after a GLP-1 version found in Gila monster venom [archived link]
That distinction matters because once GLP-1s are framed as longevity drugs rather than treatments for specific medical conditions, people may increasingly turn to unregulated, compounded versions that arent made by the manufacturers of brand-name drugs
[DOI] [PubMed] [Google Scholar] 24.Byun S., Maric I., Brchers S., Sotzen M.R., Olekanma D., Hayes M.R., Skibicka K.P
GLP-1 medications reduce appetite and slow gastric emptying by mimicking a naturally occurring intestinal hormone
As mentioned, the majority of the research on GLP-1s for PCOS has been in folks who have a higher weight, so its not clear how much of the benefits would translate to people with the condition who fall at lower weights, nor is it known whether the latter folks can safely take these drugs
The first encouraging human signal came from Athauda and colleagues in 2017
