Nutrients 13 , 3947 (2021)
Figure 7 An increase in aspartate but a decrease in glutamate and glutamine contents and synthesis has been observed in brain cortex from 17-day-old succinic-semialdehyde dehydrogenase-deficient mice together with a pronounced decrease (40%) in glutamine synthetase expression, whereas GABA production was virtually unaffected (Chowdhury et al., 3A,B follows that reduction of glutamate production, including initial transamination from -ketoglutarate might explain both the increase in aspartate content and the reduced glutamine synthetase expression
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