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43 Superoxide dismutases (SODs) are produced in high concentrations by aerobic microorganisms, such as Corynebacterium glutamicum

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Among the biological barriers, targeting the intestinal barrier represents the most promising and straightforward approach, given the direct interactions between gut microbiota and the intestinal barrier

This approach reduces medication exposure and cost but requires disciplined lifestyle adherence during off periods

Results indicated rotenone induced robust ROS generation (Fig