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On March 18, 2026, the FDA released a landmark draft guidance: "General Considerations for the Use of New Approach Methodologies (NAMs) in Drug Development." For small-to-midsize biotechs, this isn't just about ethicsits about capital efficiency and regulatory speed

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And medication should be used temporarily and sparingly whenever possible

Once Wegovy has been removed from refrigeration, the clock starts ticking, and it should be used within those 28 days to ensure its efficacy