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RT-qPCR showed that RhoA knockdown enhanced IL-1-induced decrease of ZO-1 and connexin 43 mRNA levels in ECs (Fig

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The function of GPX4 is precisely regulated by nuclear factor E2-related factor 2 (NRF2), a key transcription factor that activates the expression of various antioxidant genes, including those encoding GSH synthetase and superoxide dismutase (SOD), facilitating the clearance of excess ROS (Xie et al., 2016

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