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751 Siracusano, G

5 Metabolic targeting therapeutic strategies Targeting T cell metabolic reprogramming as a therapeutic strategy has advanced significantly in the fields of immunotherapy and autoimmune diseases in recent years

Most charges reflect deliberate M&A spend (Centessa, Orna, Kelonia, Ajax) that expands the pipeline

Monitoring and adjustment protocols should include: Weight and vital signs at each visit (initially monthly, then quarterly) Assessment of medication tolerance and adherence Evaluation of eating behaviors and physical activity Laboratory monitoring as outlined previously Reassessment of weight-related comorbidities Realistic expectations should be established through shared decision-making

The phase 2 trials clearly demonstrated a dose-dependent response, with higher doses leading to greater weight loss

Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action