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Similarly, in the UK Prospective Diabetes Study (UKPDS), six years of intensive therapy with insulin, sulfonylureas (SU), or metformin in patients with T2D reduced the risk of retinopathy, yielding an approximately 31% risk reduction for every 1% decrease in HbA1c [48]

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The goal is to allow the body time to adapt while gathering data on your tolerance, appetite response, and gastrointestinal effects

Koeller KK, Rosenblum RS, Morrison AL