As one expert says, Regular monitoring is essential to tailor Vitamin B12 therapy to individual patient needs and prevent over- or under-treatment. Response-Based Dosing Strategies We adjust Vitamin B12 doses based on how well the patient responds
Larun L, Brurberg KG, Odgaard-Jensen J, Price JR
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[55] established a rat kidney stone model by injecting glyoxalate and found that the mitochondria in rat RTECs became smaller and increased in membrane density, and the mitochondria were severely damaged
These phenomena, coupled with the re-development of overweight or obesity and poor glycaemic control when not on therapy, might increase the long-term risk of complications
PMC 6543499