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Hormones shift

In December 2024 , the FDA determined that AOD-9604 (both free base and acetate forms) should not be included on the 503A Bulks List for pharmaceutical compounding, citing concerns over limited long-term safety data, peptide impurities, and potential immunogenicity

Other storage sites include the kidney, heart, spleen, and brain

Its role as an NNMT inhibitor highlights effects on metabolic function, endurance, and healthy aging

27 October 2015

Some suggest AOD 9604 may preferentially target stubborn fat cells (areas with higher fat storage) and may also exert beneficial effects on cartilage/ bone/ connective tissue (though those are more speculative)