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It was previously reported that TSA could restore the deacetylation of H4 histone and increase the transcriptional level of glutamate receptor 2 (GluR2) in the hippocampal CA3 subregion in a rat model of pilocarpine-induced SE, thus attenuating seizure-induced neuronal injury [143]

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Due to this, redox buffering systems such as the thioredoxin and glutathione systems, and antioxidant enzymes such as catalase and superoxide dismutase are often deregulated/overexpressed to compensate