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BARTHEL, E

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However, there is only one approved drug, setmelanotide for POMC-LEPR deficiency [10], and there is no treatment for other POMC-MC4R pathway-deficient diseases, such as POMC-null, MSH-deficiency, and patients with PWS with obesity

0.380.009 M g -1 FW (2.71-times), which also exceeded the content observed in the corresponding bulk treatment (0.210.010 M g -1 FW)

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As described below, ROS may uncouple the eNOS-catalyzed reduction of molecular oxygen from the oxidation of L-arginine, resulting in the paradoxical production of the ROS superoxide anion instead of the reducing NO