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NAMPT inhibitors are primarily explored for their anti-cancer properties, as they reduce NAD + levels and impair energy metabolism and survival of cancer cells 214

GLP-1 receptor agonists may offer a new approach that can complement existing topical, systemic and biologic treatment options. Across the trials, clinicians treated participants with one of three GLP-1s 81.5% received semaglutide (Wegovy, Novo Nordisk), 17.4% received liraglutide and 1% received tirzepatide (Zepbound, Eli Lilly) at varying dosages and treatment durations

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The liver cells showed large oil and small fat droplets were diffused in ob/ob-GAN NASH mice