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Post-inflammatory Hyperpigmentation: These dark patches develop after an injury or inflammation, such as acne scars

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Due to the N-terminal truncation, PYY (3-36) shows high selectivity and affinity for Y2 receptors (45), retaining part of the activity on Y5 receptors (46), but the binding ability to Y1 and Y4 receptors is greatly reduced (47)

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10.1016/j.jep.2015.06.042 59

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Desensitization and Diminished Effects IGF-1 receptor downregulation can occur with chronic use, diminishing results over time and increasing the need for cycling or periodization

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