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In apoptosis, the opening of the mitochondrial permeability transition pore (MPTP), which is mediated by oxidative stress, triggers a cascade of events, including Ca 2+ efflux, collapse of mitochondrial membrane potential, enhanced ROS formation, and the release of cytochrome c along with other pro-apoptotic molecules into the cytoplasm (Giorgi et al., 2012)

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doi: 10.1056/NEJMoa2032183, 160 WilliamsE

In particular, the SCCS opinion indicates that the potential genotoxicity and carcinogenicity of fullerenols cannot be ruled out [14]