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GSH depletion has been confirmed to precede the dysfunction of mitochondrial complex I and lowered dopamine levels

Sex hormone treatment during menopause transition helps reverse the deleterious effects of the drop in estradiol (212)

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B12 is a cofactor for the enzyme that converts methylmalonyl-CoA to succinyl-CoA

Determination of serum biochemical parameters Serum BUN (mg/dl), creatinine(mg/dl), uric acid(mg/dl), Ca (mg/dl), P(mg/dl) and total protein (g/dl) were measured at the end of the study by an enzymatic colorimetric assays with a DIRUI (CS-T240, China) auto-clinical chemistry-analyzer and commercial diagnostic kit Biosystem company, Spain