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Tang H, Donahoo WT, DeKosky ST, Lee YA, Kotecha P, Svensson M, Bian J, Guo J (2025) GLP-1RA and SGLT2i Medications for Type 2 Diabetes and Alzheimer Disease and Related Dementias

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If your current daily dose is not effective, the solution is a dose increase at your next titration step, not doubling the frequency

We found that GEP44 exhibits biased agonism at the Y2-R, as documented by its inability to induce Y2-R-mediated internalization