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CURRENT BEST METHOD TO DIAGNOSIS While a normal TSH cannot be used as a reliable indicator of global tissue thyroid effect, even a minimally elevated TSH (above 2 mU/L) demonstrates that there is a diminished intra-pituitary T3 level and is a clear indication (except in unique situations such as a TSH-secreting tumor) that the rest of the body is suffering from inadequate thyroid activity because the pituitary T3 level is always significantly higher than the rest of the body

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It is also listed on the PBS for patients who fulfill the following key clinical criteria: an eGFR of 25 mL/min/1.73 m 2 or greater an ACR of 22.6 mg/mmol or greater must be on a stable dose of either an ACE inhibitor or ARB must not have established heart failure with reduced ejection fraction must be on an SGLT-2 inhibitor unless medically contraindicated or intolerant (please refer to the full PBS clinical criteria at: Combination therapy Some evidence suggests that combination therapy with SGLT-2 inhibitors and mineralocorticoid receptor antagonists in patients with type 2 diabetes and CKD reduces the risk of CV events and the mineralocorticoid receptor antagonist-associated risk of hyperkalaemia without a significant interaction between the two drugs

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6A), as reported in mice with global FGF21 deletion 31