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these effects were abrogated in Glp1r-null mice on the same diet

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These findings are corroborated by studies conducted on leptin-resistant, obese, hypertensive ZSF1 rats, which develop HFpEF, underscoring that myocardial endothelial dysfunction plays a significant role in the pathogenesis of HFpEF[91]

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doi:10.1093/jhmas/jrj039