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Figure 9 The DEN therapy largely, although not completely, restored the youthful state of the neuronal metabolic system but not their action potential generation

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Gonadorelin Gonadorelin mimics natural gonadotropin-releasing hormone to trigger luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release from the pituitary

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158,161,164,165 However, activating multiple receptors may lead to more complex side effects, and in some experiments, dual and triple agonists have indeed shown more severe side effects