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Abstract Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors

Hyperprolactinemia is associated with insulin resistance which improves with dopamine agonist therapy which might be related to the therapy associated weight loss and an activation of insulin signaling (5962)

Many people are also choosing to explore weight management without medication

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Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation