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Severe insulin resistance, particularly in patients with significant visceral adiposity or conditions like polycystic ovary syndrome, can attenuate tirzepatide's effectiveness

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Immunocompromised individuals, critically ill patients, those with severe acute pancreatitis, people with central venous catheters, and individuals with short bowel syndrome should avoid probiotics without medical supervision

29 Despite this, metformin for the prevention of AIWG is not routinely offered in psychiatric practice

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