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Phase 1: tirzepatide establishment (weeks 1-4) Focus exclusively on adjusting to tirzepatide

On top of that, the SURPASS-3 MRI sub study showed that a substantial fraction of the lean mass lost on tirzepatide was intramuscular fat, not muscle tissue

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Nausea remains the most commonly reported side effect of GLP-1 receptor agonists, occurring in roughly 25-40% of users during the first weeks of treatment

Management: Monitor blood pressure regularly

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