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We demonstrated that TrkB signalling in these neurons is essential to maintain normal locomotor behaviour consistent with the initial hyperkinetic symptoms of HD and suggested that TrkB signalling deficiency may contribute effectively to HD motor symptoms 13

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J Am Pharm Assoc 63(5):16431645 Lee YS, Jun HS (2016) Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control

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However, the efficacy of nasal administration may differ compared to other methods, and individual responses may vary

These responses typically show up within minutes to hours after eating