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NPs in Texas must maintain a prescriptive authority agreement (PAA) with a supervising physician to prescribe medications, and are required to practice within 75 miles of their supervising physician in most settings

According to NICE NG28, GLP-1 receptor agonist treatment should only be continued if there is beneficial metabolic response (HbA1c reduction of at least 11 mmol/mol [1.0%] and weight loss of at least 3% of initial body weight at 6 months)

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Presynaptically, Y2 receptors function as autoinhibitory receptors regulating neurotransmitter release, participating in negative feedback control of energy balance